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Lorazepam belongs to a group of drugs called benzodiazepines used for the management of anxiety. Ativan (lorazepam) is readily absorbed with an absolute bioavailability of 90 percent. Peak concentrations in plasma occur approximately 2 hours following administration and the peak plasma level of lorazepam from a 2 mg dose is approximately 20 mg/ml. Furthermore the mean half-life of unconjugated lorazepam in human plasma is about 12 hours and for its major metabolite, lorazepam glucuronide, about 18 hours. At clinically relevant concentrations, lorazepam is approximately 85% bound to plasma proteins and Ativan (lorazepam) is rapidly conjugated at its 3-hydroxy group into lorazepam glucuronide which is then excreted in the urine.
INDICATION AND USAGE
short-term relief of the symptoms of excessive anxiety or anxiety associated with depressive symptoms. Anxiety or tension associated with the stress of everyday life,Short-Term Treatment of Insomnia and chronic insomia, Anxiety Relief and Anterograde Amnesia,Status Epilepticus,Chemotherapy-Induced Nausea/Vomiting,seizure.
Sedation,Dizziness, Unsteadiness, Weakness, Fatigue, Drowsiness,Confusion, Disorientation, Depression, Suicidal ideation/attempt,Sleep apnea, Extrapyramidal symptoms, Respiratory,depression Dysarthria,Hypotension,Blood dyscrasias, Increased bilirubin, Increased liver transaminases, Nausea, change in appetite.
Ativan (lorazepam) is contraindicated in patients with
1 hypersensitivity to benzodiazepines orto any components of the formulation.
2 Acute narrow-angle glaucoma.
3 Myasthenia graviS
4 Pregnancy-This medicine can cause birth defects and your baby could also become dependent on the drug which can cause life- threatening withdrawal symptoms in the baby after birth.
5 A history of depression or suicidal thoughts or behavior
6 Asthma or other breathing disorder
The central difference between Ativan and Xanax is Ativan leaves a person’s system more quickly, reducing the chance of toxicity or side effect.Ativam also has fewer unfavorable interactions with other medications when compared to Xanax.